Clinical biology of the pituitary adenoma

S Melmed, UB Kaiser, MB Lopes, J Bertherat… - Endocrine …, 2022 - academic.oup.com
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

[HTML][HTML] The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions

JA Sheng, NJ Bales, SA Myers, AI Bautista… - Frontiers in behavioral …, 2021 - frontiersin.org
The hypothalamic-pituitary adrenal axis is a complex system of neuroendocrine pathways
and feedback loops that function to maintain physiological homeostasis. Abnormal …

[HTML][HTML] Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development

S Zhang, Y Cui, X Ma, J Yong, L Yan, M Yang… - Nature …, 2020 - nature.com
The anterior pituitary gland plays a central role in regulating various physiological
processes, including body growth, reproduction, metabolism and stress response. Here, we …

Self-formation of functional adenohypophysis in three-dimensional culture

H Suga, T Kadoshima, M Minaguchi, M Ohgushi… - Nature, 2011 - nature.com
The adenohypophysis (anterior pituitary) is a major centre for systemic hormones. At
present, no efficient stem-cell culture for its generation is available, partly because of …

The paraventricular nucleus of the hypothalamus: development, function, and human diseases

C Qin, J Li, K Tang - Endocrinology, 2018 - academic.oup.com
The paraventricular nucleus of the hypothalamus (PVH), located in the ventral diencephalon
adjacent to the third ventricle, is a highly conserved brain region present in species from …

[HTML][HTML] Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

C Ozone, H Suga, M Eiraku, T Kadoshima… - Nature …, 2016 - nature.com
Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and
negative regulators are indispensable for homeostasis. For this reason, generating human …

SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland

T Fauquier, K Rizzoti, M Dattani… - Proceedings of the …, 2008 - National Acad Sciences
The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing
hormonal demands throughout life. There is circumstantial evidence that multipotent adult …

Social stimuli induce activation of oxytocin neurons within the paraventricular nucleus of the hypothalamus to promote social behavior in male mice

SL Resendez, VMK Namboodiri, JM Otis… - Journal of …, 2020 - Soc Neuroscience
Oxytocin (OT) is critical for the expression of social behavior across a wide array of species;
however, the role of this system in the encoding of socially relevant information is not well …

GnRH signaling, the gonadotrope and endocrine control of fertility

SP Bliss, AM Navratil, J Xie, MS Roberson - Frontiers in …, 2010 - Elsevier
Mammalian reproductive cycles are controlled by an intricate interplay between the
hypothalamus, pituitary and gonads. Central to the function of this axis is the ability of the …

In vitro organogenesis in three dimensions: self-organising stem cells

Y Sasai, M Eiraku, H Suga - Development, 2012 - journals.biologists.com
Organ formation during embryogenesis is a complex process that involves various local cell-
cell interactions at the molecular and mechanical levels. Despite this complexity …