Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …

Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …

Objective Osteoarthritis (OA) is a degenerative joint disease characterized by the
progressive loss of articular cartilage. While macroscale degradation of the cartilage …

Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and
progression. Identifying alterations in biomechanical factors and their complex interactions is …

Virtual representations of the knee joint can provide clinicians, scientists, and engineers the
tools to explore mechanical functions of the knee and its tissue structures in health and …

Due to the biphasic viscoelastic nature of cartilage, joint loading may result in deformations
that require times on the order of hours to fully recover. Thus, cartilaginous tissues may …

Computational mechanics has been advanced in every area of orthopedic biomechanics.
The objective of this paper is to provide a general review of the computational models used …

The knee joint is a complex mechanical system, and computational modelling can provide
vital information for the prediction of disease progression and of the potential for therapeutic …

Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with
variable clinical presentation, progression, and response to therapeutic intervention. This …

Complementary to experimental studies, computational biomechanics has become useful
tool for the understanding of human foot biomechanics and pathomechanics. Its findings …