Millions of patients suffer yearly from bone fractures and disorders such as osteoporosis or
cancer, which constitute the most common causes of severe long-term pain and physical …

Ligaments provide stability to the human knee joint and play an essential role in restraining
motion during daily activities. Compression-tension nonlinearity is a well-known …

Meniscal tears are common injuries, and while partial meniscectomy is a frequent treatment
option, general meniscus loss is a risk factor for the development of osteoarthritis. The goal …

Osteoarthritis (OA) is a degenerative disease that affects the synovial joints, especially the
knee joint, diminishing the ability of patients to perform daily physical activities …

Biomedical research and clinical practice are struggling to cope with the growing complexity
that the progress of health care involves. The most challenging diseases, those with the …

Osteoarthritis (OA), a degenerative joint disease, is the most common chronic condition of
the joints, which cannot be prevented effectively. Computational modeling of joint …

Advances in computational mechanics, constitutive modeling, and techniques for subject-
specific modeling have opened the door to patient-specific simulation of the relationships …

Objective Obesity is an important risk factor for osteoarthritis (OA) and is associated with
changes in both the biomechanical and inflammatory environments within the joint …

Regional variations in the composition and architecture of the extracellular matrix (ECM) and
pericellular matrix (PCM) of the knee meniscus play important roles in determining the local …

Mechanical signals experienced by chondrocytes (articular cartilage cells) modulate cell
synthesis and cartilage health. Multi-scale modeling can be used to study how forces are …