The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some
cases, treatment can increase patient survival and reduce cancer recurrence, in many …

Despite the advancement of treatment modalities, many cancer patients experience tumor
recurrence and metastasis at regional or distant sites. Evolving understanding of tumor …

Eighty percent of malignant tumors that develop in the central nervous system are malignant
gliomas, which are essentially incurable. Here, we discuss how recent sequencing studies …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor
progression. However, regulation of CSCs stemness is not entirely understood. Here, we …

Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew
and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms …

The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …

Cancer cell molecular mimicry of stem cells (SC) imbues neoplastic cells with enhanced
proliferative and renewal capacities. In support, numerous mediators of SC self-renewal …