The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …

Pulmonary arterial hypertension (PAH) is a severe and progressive disease that usually
culminates in right heart failure and death if left untreated. Although there have been …

The sulfonylurea receptor 1 (Sur1)-NC Ca-ATP channel plays a central role in necrotic cell
death in central nervous system (CNS) injury, including ischemic stroke, and traumatic brain …

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding
cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …

Endothelial cells and smooth muscle cells of resistance arteries mediate opposing
responses to mechanical forces acting on the vasculature, promoting dilation in response to …

5-Fluorouracil (5-Fu) is commonly used in the chemotherapy of colorectal cancer (CRC), but
resistance to 5-Fu occurs in most cases, allowing cancer progression. Suppressing ABCB1 …

Itching is a sensory phenomenon characterized by an unpleasant sensation that makes you
want to scratch the skin, and chronic itching diminishes the quality of life. In recent studies …

Transient receptor potential (TRP) channels are a superfamily of cation transmembrane
proteins that are expressed in many tissues and respond to many sensory stimuli. TRP …

Pulmonary vasoconstriction and vascular remodeling are two major causes for elevated
pulmonary vascular resistance and pulmonary arterial pressure in patients with idiopathic …