This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …

Current single-cell RNA-sequencing approaches have limitations that stem from the
microfluidic devices or fluid handling steps required for sample processing. We develop a …

Escherichia coli is a normal inhabitant of the human gut. However, E. coli strains of
phylogenetic group B2 harbor a genomic island called “pks” that codes for the production of …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of
transcription. In this study, we identified a 70-kDa Cyclin K (CycK) that binds Cdk12 and …

Breast cancer is one of the familiar diseases in women. Incidence and mortality due to
cancer, particularly breast cancer has been increasing for last 50 years, even though there is …

Senescence was classically defined as an irreversible cell cycle arrest in G1 phase (G1 exit)
triggered by eroded telomeres in aged primary cells. The molecular basis of this G1 arrest is …

Cancer is the principal cause of death and its incidence is increasing continuously
worldwide. Various treatment approaches are in practice to treat cancer, but these treatment …