[HTML][HTML] A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute …
JF Seymour, DW Kim, E Rubin, A Haregewoin… - Blood cancer …, 2014 - nature.com
Aurora kinase overexpression has been observed in patients with hematologic
malignancies. MK-0457, a pan-aurora kinase inhibitor that also inhibits the ABL T315I …
malignancies. MK-0457, a pan-aurora kinase inhibitor that also inhibits the ABL T315I …
D-limonene possesses cytotoxicity to tumor cells but not to hepatocytes.
B Shah, MV Shaikh, K Chaudagar… - Polish Annals of …, 2019 - search.ebscohost.com
Introduction: K562, human chronic myeloid leukemia cell line shows presence of
constitutively active BCR-ABL gene. D-limonene, monoterpenes obtained from essential oils …
constitutively active BCR-ABL gene. D-limonene, monoterpenes obtained from essential oils …
Chronic myeloid leukemia: cytogenetic methods and applications for diagnosis and treatment
CM Morris - Cancer Cytogenetics: Methods and Protocols, 2011 - Springer
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease caused by
recombination between the BCR gene on chromosome 22 and the ABL1 gene on …
recombination between the BCR gene on chromosome 22 and the ABL1 gene on …
PTD-OD-HA 融合蛋白对bcr/abl 阳性细胞凋亡的影响
黄峥兰， 季茂胜， 袁颖， 黄世峰， 刘钉宾， 曾建明… - 肿瘤, 2010 - cqvip.com
目的: 研究含有蛋白转导域(protein transduction domain, PTD), 寡聚化结构域(oligomerization
domain, OD) 和HA 标签的PTD-OD-HA 融合蛋白对几种bcr/abl 阳性细胞株细胞凋亡的影响 …
domain, OD) 和HA 标签的PTD-OD-HA 融合蛋白对几种bcr/abl 阳性细胞株细胞凋亡的影响 …
Chronic myelogenous leukemia in patients with MPL or JAK2 mutation-positive myeloproliferative neoplasm.
The article discusses case studies on the development of chronic myelogenous leukemia
(CML) among patients suffering from mutation-positive myeloproliferative neoplasm. Topics …
(CML) among patients suffering from mutation-positive myeloproliferative neoplasm. Topics …
[HTML][HTML] Practical Laboratory Tools for Monitoring of BCR-ABL1 Transcripts and Tyrosine Kinase (TK) Domain Mutations in Chronic Myeloid Leukemia Patients …
N Limsuwanachot, A Kongruang… - Asian Pacific Journal …, 2020 - ncbi.nlm.nih.gov
Objective: The genetic hallmark of CML is known as the appearance of t (9; 22)(q34. 1; q11.
2)(BCR-ABL1) which is present in more than 95% of cases. Here, we demonstrated practical …
2)(BCR-ABL1) which is present in more than 95% of cases. Here, we demonstrated practical …
Optimizing outcomes in patients with chronic myeloid leukemia in chronic phase: comparative safety profiles of newer agents
K Kelly, R Swords, D Mahalingam… - Leukemia & lymphoma, 2010 - Taylor & Francis
Imatinib is broadly used in the frontline treatment of chronic myeloid leukemia (CML).
Although long-term safety and efficacy have been established, some patients will not …
Although long-term safety and efficacy have been established, some patients will not …
From hen house to bedside: tracing Hanafusa's legacy from avian leukemia viruses to SRC to ABL and beyond
The discovery of the Src oncogene was the first step on a long journey toward improved
cancer chemotherapy. In this review, we explore Src and BCR-ABL, signal transduction, and …
cancer chemotherapy. In this review, we explore Src and BCR-ABL, signal transduction, and …
Rapid quantitative detection of the T315I mutation in patients with chronic myelogenous leukemia
L Yin, D Dittman, A Chenn - Diagnostic Molecular Pathology, 2012 - journals.lww.com
Acquired resistance to tyrosine kinase inhibitors (TKIs) in the treatment of chronic
myelogenous leukemia (CML) is frequently caused by point mutations in the ABL kinase …
myelogenous leukemia (CML) is frequently caused by point mutations in the ABL kinase …
Molecular diagnostics: parallels between infectious disease and emerging oncology testing
JA Lefferts, GJ Tsongalis - Expert Opinion on Medical Diagnostics, 2010 - Taylor & Francis
Evolving molecular techniques used in the clinical laboratory are becoming increasingly
important across nearly all fields of medicine. An increased understanding of carcinogenesis …
important across nearly all fields of medicine. An increased understanding of carcinogenesis …