Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development

SM Stefan, M Rafehi - Drug Development Research, 2024 - Wiley Online Library
At the core of complex and multifactorial human diseases, such as cancer, metabolic
syndrome, or neurodegeneration, are multiple players that cross‐talk in robust biological …

[HTML][HTML] Host kinase regulation of Plasmodium vivax dormant and replicating liver stages

EKK Glennon, L Wei, W Roobsoong, VI Primavera… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Upon transmission to the liver, Plasmodium vivax parasites form replicating schizonts, which
continue to initiate blood-stage infection, or dormant hypnozoites that reactivate weeks to …