The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

B cells play a central role in humoral immunity but also have antibody-independent
functions. Studies to date have focused on B cells in blood and secondary lymphoid organs …

The traditional definition of natural antibodies (NAbs) states that these antibodies are
present prior to the body encountering cognate antigen, providing a first line of defense …

Aerobic organisms need to maintain cellular redox homeostasis. Glutathione peroxidase-4
(Gpx4) has the unique ability to protect cells against lipid peroxidation. Here, we show that …

Modern immunologic research increasingly requires high-dimensional analyses to
understand the complex milieu of cell types that comprise the tissue microenvironments of …

Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied
the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated …

The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …

This article reviews immunological memory cells, currently represented by T and B
lymphocytes and natural killer (NK) cells, which determine a rapid and effective response …

In contrast to adaptive antibodies, natural antibodies are present in a non-immunised
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …