Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Guanine rich regions of oligonucleotides fold into quadruple-stranded structures called G-
quadruplexes (G4s). Increasing evidence suggests that these G4 structures form in vivo and …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Abstract G-quadruplexes (G4) are secondary four-stranded DNA helical structures
consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …

Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and
better understanding various biological systems. Therefore, it has become increasingly …

G-quadruplex, a structurally unique structure in nucleic acids present all throughout the
human genome, has sparked great attention in therapeutic investigations. Targeting G …

The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …