Over the past decade, appreciation of the roles of G-quadruplex (G4) structures in cellular
regulation and maintenance has rapidly grown, making the establishment of robust methods …

In this study, we raised a brand-new principle termed disaggregation-and-binding-induced
emission (DBIE) for the design of G4 fluorescent probes, which may overcome the …

The primary oncogenic event in∼ 85% of Ewing sarcomas is a chromosomal translocation
that generates a fusion oncogene encoding an aberrant transcription factor. The exact …

Reactive oxygen species (ROS) have been implicated in numerous pathological processes
and their homeostasis facilitates the dynamic balance of intracellular redox states. Among …

Genome integrity is essential for proper cell function such that genetic instability can result in
cellular dysfunction and disease. Mutations in the human genome are not random, and …

Probing the kinetics of ligand binding to biomolecules is of paramount interest in biology and
pharmacology. Measurements of such kinetic processes provide information on the rate …

Abstract G-quadruplex (G4) structures are often enriched in cancer-driving genes with
elevated transcriptional activity, which are now treated as potential targets for cancer …

Fluorescence imaging is constantly searching for new far-red emitting probes whose turn-on
response is selective upon the interaction with specific biological targets. Cationic push-pull …

The review summarizes advances in the development of low-molecular-weight ligands for G-
quadruplex (G4) nucleic acid structures published in the past five years. Main chemical …

A novel strategy to design “turn-on” fluorescent receptors for G-quadruplexes of DNA is
presented, which relies on the connection of phosphate binding macrocycles (PBM) with …