Spinal cord repair: advances in biology and technology

G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury

PG Nagappan, H Chen, DY Wang - Military Medical Research, 2020 - Springer
Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …

Targeted neurotechnology restores walking in humans with spinal cord injury

FB Wagner, JB Mignardot, CG Le Goff-Mignardot… - Nature, 2018 - nature.com
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we
introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control …

Motor recovery after activity-based training with spinal cord epidural stimulation in a chronic motor complete paraplegic

E Rejc, CA Angeli, D Atkinson, SJ Harkema - Scientific reports, 2017 - nature.com
The prognosis for recovery of motor function in motor complete spinal cord injured (SCI)
individuals is poor. Our research team has demonstrated that lumbosacral spinal cord …

Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation

Y Zheng, YR Mao, TF Yuan, DS Xu… - Neural regeneration …, 2020 - journals.lww.com
Spinal cord injury is linked to the interruption of neural pathways, which results in
irreversible neural dysfunction. Neural repair and neuroregeneration are critical goals and …

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injury

JT Hachmann, A Yousak, JJ Wallner… - Journal of …, 2021 - journals.physiology.org
Spinal cord injury (SCI) commonly results in permanent loss of motor, sensory, and
autonomic function. Recent clinical studies have shown that epidural spinal cord stimulation …

Exercise-induced plasticity in signaling pathways involved in motor recovery after spinal cord injury

JN Bilchak, G Caron, MP Côté - International journal of molecular …, 2021 - mdpi.com
Spinal cord injury (SCI) leads to numerous chronic and debilitating functional deficits that
greatly affect quality of life. While many pharmacological interventions have been explored …

[HTML][HTML] Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation

AS Hofer, ME Schwab - Current opinion in neurology, 2019 - journals.lww.com
Promising treatment options have emerged from research in recent years using
neurostimulation to enable or enhance intense training. However, characterizing long-term …

Rehabilitation following spinal cord injury: how animal models can help our understanding of exercise-induced neuroplasticity

K Loy, FM Bareyre - Neural regeneration research, 2019 - journals.lww.com
Spinal cord injury is a devastating condition that is followed by long and often unsuccessful
recovery after trauma. The state of the art approach to manage paralysis and concomitant …