A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …

Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a
major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma …

A photoplethysmogram (PPG) contains a wealth of cardiovascular system information, and
with the development of wearable technology, it has become the basic technique for …

Hypertension, particularly midlife high blood pressure, has been related to a higher risk of
cognitive decline and dementia, including Alzheimer disease. However, these associations …

Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in myriad
physiological processes including the regulation of vascular tone, neurotransmission …

Objective Arterial stiffness has been associated with evidence of cerebral small vessel
disease (cSVD) and fibrillar β-amyloid (Aβ) deposition in the brain. These complex …