[HTML][HTML] Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies

MM Rahman, MR Islam, S Shohag, MT Ahasan… - Biomedicine & …, 2022 - Elsevier
Cancer is the world's second-leading cause of death, and the involvement of microbes in a
range of diseases, including cancer, is well established. The gut microbiota is known to play …

[HTML][HTML] Enabling technology and core theory of synthetic biology

XE Zhang, C Liu, J Dai, Y Yuan, C Gao, Y Feng… - Science China Life …, 2023 - Springer
Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

[HTML][HTML] Engineering host microbiome for crop improvement and sustainable agriculture

S Kaul, M Choudhary, S Gupta, MK Dhar - Frontiers in Microbiology, 2021 - frontiersin.org
Dynamic consortium of microbial communities (bacteria, fungi, protists, viruses, and
nematodes) colonizing multiple tissue types and coevolving conclusively with the host plant …

Predicting drug-microbiome interactions with machine learning

LE McCoubrey, S Gaisford, M Orlu, AW Basit - Biotechnology advances, 2022 - Elsevier
Pivotal work in recent years has cast light on the importance of the human microbiome in
maintenance of health and physiological response to drugs. It is now clear that …

Gut microbiota in ischemic stroke: role of gut bacteria-derived metabolites

W Zhang, XY Dong, R Huang - Translational stroke research, 2023 - Springer
Ischemic stroke (IS) remains a leading cause of death and long-term disability globally.
Several mechanisms including glutamate excitotoxicity, calcium overload …

[HTML][HTML] Gut microbiome and common variable immunodeficiency: few certainties and many outstanding questions

G Varricchi, R Poto, G Ianiro, A Punziano… - Frontiers in …, 2021 - frontiersin.org
Common variable immunodeficiency (CVID) is the most common symptomatic primary
antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM …

[HTML][HTML] Machine learning predicts drug metabolism and bioaccumulation by intestinal microbiota

LE McCoubrey, S Thomaidou, M Elbadawi, S Gaisford… - Pharmaceutics, 2021 - mdpi.com
Over 150 drugs are currently recognised as being susceptible to metabolism or
bioaccumulation (together described as depletion) by gastrointestinal microorganisms; …

Evolutionary consequences of microbiomes for hosts: impacts on host fitness, traits, and heritability

AM O'Brien, JR Laurich, ME Frederickson - Evolution, 2024 - academic.oup.com
An organism's phenotypes and fitness often depend on the interactive effects of its genome
(G h⁢ o⁢ s⁢ t), microbiome (G m⁢ i⁢ c⁢ r⁢ o⁢ b⁢ e), and environment (E). These G× G, G× …

[HTML][HTML] Microbiome engineering: a promising approach to improve coral health

J Li, Q Yang, J Dong, M Sweet, Y Zhang, C Liu… - Engineering, 2022 - Elsevier
The world's coral reefs are threatened by the cumulative impacts of global climate change
and local stressors. Driven largely by a desire to understand the interactions between corals …

[HTML][HTML] A data-driven approach for predicting the impact of drugs on the human microbiome

YM Algavi, E Borenstein - Nature Communications, 2023 - nature.com
Many medications can negatively impact the bacteria residing in our gut, depleting
beneficial species, and causing adverse effects. To guide personalized pharmaceutical …