Regular or frequent use of analgesics and acute antimigraine drugs can increase the
frequency of headache, and induce the transition from episodic to chronic headache or …

At least 3 million Americans sustain a mild traumatic brain injury (mTBI) each year, and 1 in
5 have symptoms that persist beyond 1 month. Standards of mTBI care have evolved rapidly …

Summary Background Through the Global Burden of Diseases, Injuries, and Risk Factors
(GBD) studies, headache has emerged as a major global public health concern. We aimed …

Background Quality clinical trials form an essential part of the evidence base for the
treatment of headache disorders. In 1991, the International Headache Society Clinical Trials …

Objective To determine the effect of erenumab, a human anti-calcitonin gene-related peptide
receptor monoclonal antibody, in patients with chronic migraine and medication overuse …

The fifth cranial nerve is the common denominator for many headaches and facial pain
pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it …

Post-traumatic headache is a common sequela of traumatic brain injury and is classified as
a secondary headache disorder. In the past 10 years, considerable progress has been …

Medication overuse in primary headache disorders is a worldwide phenomenon and has a
role in the chronification of headache disorders. The burden of disease on individuals and …

Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …

Migraine is one of the most common diseases worldwide and, importantly, a major cause of
disability. This translates into a huge clinical and economic burden to individuals and …