Ricin and Ricinus communis in pharmacology and toxicology-from ancient use and “Papyrus Ebers” to modern perspectives and “poisonous plant of the year 2018”

H Franke, R Scholl, A Aigner - Naunyn-Schmiedeberg's archives of …, 2019 - Springer
While probably originating from Africa, the plant Ricinus communis is found nowadays
around the world, grown for industrial use as a source of castor oil production, wildly …

Recent Advances in the Detection of Food Toxins Using Mass Spectrometry

V Ahuja, A Singh, D Paul, D Dasgupta… - Chemical Research …, 2023 - ACS Publications
Edibles are the only source of nutrients and energy for humans. However, ingredients of
edibles have undergone many physicochemical changes during preparation and storage …

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

BG Dorner, R Zeleny, K Harju, JA Hennekinne… - TrAC Trends in …, 2016 - Elsevier
Biological toxins are a heterogeneous group of compounds that share commonalities both
with biological and chemical agents. Based on their availability, toxicity, and the lack of …

Top-down mass spectrometry for trace level quantification of staphylococcal enterotoxin A variants

D Lefebvre, F Fenaille, D Merda… - Journal of Proteome …, 2021 - ACS Publications
We addressed here the need for improved sensitivity of top-down mass spectrometry for
identification, differentiation, and absolute quantification of sequence variants of SEA, a …

Rapid, sensitive and reliable ricin identification in serum samples using LC–MS/MS

L Feldberg, E Elhanany, O Laskar, O Schuster - Toxins, 2021 - mdpi.com
Ricin, a protein derived from the seeds of the castor bean plant (Ricinus communis), is a
highly lethal toxin that inhibits protein synthesis, resulting in cell death. The widespread …

Rapid detection of abrin toxin and its isoforms in complex matrices by immuno-extraction and quantitative high resolution targeted mass spectrometry

EM Hansbauer, S Worbs, H Volland, S Simon… - Analytical …, 2017 - ACS Publications
Abrin expressed by the tropical plant Abrus precatorius is highly dangerous with an
estimated human lethal dose of 0.1–1 μg/kg body weight. Due to the potential misuse as a …

A simple, fast and portable method for electrochemical detection of adenine released by ricin enzymatic activity

G Oliveira, JM Schneedorf - Toxins, 2021 - mdpi.com
International authorities classify ricin toxin present in castor seed as a potential agent for use
in bioterrorism. Therefore, the detection, identification, and characterization of ricin in various …

An international proficiency test to detect, identify and quantify ricin in complex matrices

S Worbs, M Skiba, J Bender, R Zeleny, H Schimmel… - Toxins, 2015 - mdpi.com
While natural intoxications with seeds of Ricinus communis (R. communis) have long been
known, the toxic protein ricin contained in the seeds is of major concern since it attracts …

Ricin-like proteins from the castor plant do not influence liquid chromatography-mass spectrometry detection of ricin in forensically relevant samples

ED Merkley, SC Jenson, JS Arce, AM Melville… - Toxicon, 2017 - Elsevier
The toxic protein ricin (also known as RCA60), found in the seed of the castor plant (Ricinus
communis) is frequently encountered in law enforcement investigations. The ability to detect …

Highly sensitive MALDI-MS measurement of active ricin: Insight from more potential deoxynucleobase-hybrid oligonucleotide substrates

J Yang, C Wang, L Luo, Z Li, B Xu, L Guo, J Xie - Analyst, 2021 - pubs.rsc.org
Herein, we report an improved MALDI-MS method for active ricin to contribute toward
countermeasures against its real threat to the public. Compared with commonly used DNA …