Radiation injury and gut microbiota-based treatment

W Wang, B Cui, Y Nie, L Sun, F Zhang - Protein & Cell, 2024 - academic.oup.com
The exposure to either medical sources or accidental radiation can cause varying degrees
of radiation injury (RI). RI is a common disease involving multiple human body parts and• …

[HTML][HTML] Role of mesenchymal stem cells and extracellular vesicles in idiopathic pulmonary fibrosis

S Kletukhina, G Mutallapova, A Titova… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial fibrotic disease that leads to
disability and death within 5 years of diagnosis. Pulmonary fibrosis is a disease with a …

Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-β/SMAD3 and PI3K/AKT signaling pathway

L Fang, H Chen, R Kong, J Que - Life sciences, 2020 - Elsevier
Pulmonary fibrosis is the end stage of many interstitial lung diseases, characterized by the
deposition of excess extracellular matrix (ECM), destruction of normal alveolar structure, and …

[HTML][HTML] Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin

A Kawara, R Mizuta, M Fujisawa, T Ito, C Li… - Scientific reports, 2020 - nature.com
The mitogen-activated protein kinase (MAPK) pathways are involved in many cellular
processes, including the development of fibrosis. Here, we examined the role of Sprouty …

Irisin attenuates P. gingivalis-suppressed osteogenic/cementogenic differentiation of periodontal ligament cells via p38 signaling pathway

X Huang, J Xiao, X Wang, Z Cao - Biochemical and biophysical research …, 2022 - Elsevier
Regeneration of periodontal hard tissues damaged by Porphyromonas gingivalis (P.
gingivalis) is essential for tooth stability and dental health. Irisin, a myokine secreted by …

A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement

X Shen, W Wu, Y Ying, L Zhou… - Australian Endodontic …, 2023 - Wiley Online Library
Investigation on the effect of Piezo1 on periodontal tissue and periodontal ligament
fibroblasts (PDLFs) under mechanical stress and the underlying mechanism. The …

Sparganii Rhizoma alleviates pulmonary fibrosis by inhibiting fibroblasts differentiation and epithelial-mesenchymal transition mediated by TGF-β1/Smad2/3 pathway

J Liu, D Gao, Q Ding, B Zhang, W Zhu, Y Shi - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Pulmonary fibrosis (PF), a lethal lung disease, can lead to
structural destruction of the alveoli until death. Sparganii Rhizoma (SR), primarily distributed …

Profile of 5-HT2A receptor involved in signaling cascades associated to intracellular inflammation and apoptosis in hepatocytes and its role in carbon tetrachloride …

Y Zhang, Y Wang, K Zhang, X Liang, J Guan, J Jin… - Cellular …, 2023 - Elsevier
Previously, we found that the 5-HT 2A receptor plays a key role in cell injury. However, the
mechanism by which the 5-HT 2A receptor mediates intracellular processes remains …

[HTML][HTML] Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways

H Xu, J Yang, M Tu, J Weng, M Xie, Z Zhou… - Frontiers in …, 2022 - frontiersin.org
Background: Vincristine (VCR) is used in the clinic as an anti-tumor drug. VCR can cause
pulmonary fibrosis (PF), leading to respiratory failure. The transformation of fibroblasts into …

[HTML][HTML] Lim mineralization protein-1 enhances the committed differentiation of dental pulp stem cells through the erk1/2 and p38 mapk pathways and bmp signaling

R Mu, B Chen, B Bi, H Yu, J Liu, J Li, M He… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Tissue regeneration is the preferred treatment for dentin and bone tissue defects. Dental
pulp stem cells (DPSCs) have been extensively studied for their use in tissue regeneration …