The role of microbiota in the development of colorectal cancer

Z Dai, J Zhang, Q Wu, J Chen, J Liu… - … journal of cancer, 2019 - Wiley Online Library
Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely
related to the intestinal microbiota. Many reports and clinical studies have shown that …

[HTML][HTML] Microbiota-immune interactions in ulcerative colitis and colitis associated cancer and emerging microbiota-based therapies

J Popov, V Caputi, N Nandeesha… - International journal of …, 2021 - mdpi.com
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is
a subtype of inflammatory bowel disease along with Crohn's disease and presents with …

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

W Zhu, N Miyata, MG Winter, A Arenales… - Journal of experimental …, 2019 - rupress.org
Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-
producing E. coli strains, are risk factors for the development of colorectal cancer. Here, we …

Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer

H Lin, X Ma, X Yang, Q Chen, Z Wen, M Yang… - International …, 2022 - Elsevier
Background Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are the most
common diseases of human digestive system. Nowadays, the influence of the inflammatory …

[HTML][HTML] Cecropin A alleviates inflammation through modulating the gut microbiota of C57BL/6 mice with DSS-induced IBD

Z Zhai, F Zhang, R Cao, X Ni, Z Xin, J Deng… - Frontiers in …, 2019 - frontiersin.org
The present study is undertaken to assess the alleviating effects of antimicrobial peptide
cecropin A on inflammatory bowel disease (IBD) in C57BL/6 mice and changes in the gut …

[HTML][HTML] Resolving the paradox of colon cancer through the integration of genetics, immunology, and the microbiota

M Fidelle, S Yonekura, M Picard, A Cogdill… - Frontiers in …, 2020 - frontiersin.org
While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory
lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to …

Good gone bad: one toxin away from disease for Bacteroides fragilis

E Valguarnera, JB Wardenburg - Journal of molecular biology, 2020 - Elsevier
The human gut is colonized by hundreds of trillions of microorganisms whose acquisition
begins during early infancy. Species from the Bacteroides genus are ubiquitous …

A potential species of next-generation probiotics? The dark and light sides of Bacteroides fragilis in health

F Sun, Q Zhang, J Zhao, H Zhang, Q Zhai… - Food Research …, 2019 - Elsevier
Bacteroides fragilis (B. fragilis) is a commensal Gram-negative obligate anaerobe that
resides in the mammalian lower gut and can profoundly affect the susceptibility of the host to …

Roles for interleukin 17 and adaptive immunity in pathogenesis of colorectal cancer

CG Hurtado, F Wan, F Housseau, CL Sears - Gastroenterology, 2018 - Elsevier
Sporadic colorectal cancer is one of the most common and lethal cancers worldwide. The
locations and functions of immune cells in the colorectal tumor microenvironment are …

[HTML][HTML] Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis

Y Lin, L Fan, Y Qi, C Xu, D Jia, Y Jiang, S Chen… - Journal of Experimental …, 2023 - Springer
Background The interplay between gut microbiota and tumor microenvironment (TME) in the
pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the …