Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Gender Differences and miRNAs Expression in Cancer: Implications on Prognosis and Susceptibility

S Caserta, S Gangemi, G Murdaca… - International Journal of …, 2023 - mdpi.com
MicroRNAs are small, noncoding molecules of about twenty-two nucleotides with crucial
roles in both healthy and pathological cells. Their expression depends not only on genetic …

γδ T cells as a potential therapeutic agent for glioblastoma

I Kang, Y Kim, HK Lee - Frontiers in Immunology, 2023 - frontiersin.org
Although γδ T cells comprise a small population of T cells, they perform important roles in
protecting against infection and suppressing tumors. With their distinct tissue-localizing …

Revolutionizing Glioblastoma Treatment: A Comprehensive Overview of Modern Therapeutic Approaches

K Sadowski, A Jażdżewska, J Kozłowski… - International Journal of …, 2024 - mdpi.com
Simple Summary Glioblastoma is one of the most dangerous tumors of the central nervous
system, and still cannot be fully overcome. We still mainly rely on standard treatments …

Integrating multisector molecular characterization into personalized peptide vaccine design for patients with newly diagnosed glioblastoma

TM Johanns, EAR Garfinkle, KE Miller… - Clinical Cancer …, 2024 - AACR
Purpose: Outcomes for patients with glioblastoma (GBM) remain poor despite multimodality
treatment with surgery, radiation, and chemotherapy. There are few immunotherapy options …

The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment

SA Dusoswa, J Verhoeff, S van Asten… - Frontiers in …, 2024 - frontiersin.org
Background Glioblastomas manipulate the immune system both locally and systemically,
yet, glioblastoma-associated changes in peripheral blood immune composition are poorly …

Pan-cancer analyses identify MIR210HG overexpression, epigenetic regulation and oncogenic role in human tumors and its interaction with the tumor …

G Yadav, R Kulshreshtha - Life Sciences, 2024 - Elsevier
Background Molecular entities showing dysregulation in multiple cancers may hold great
biomarker or therapeutic potential. There is accumulating evidence that highlights the …

[HTML][HTML] Navigating the immune challenge in glioblastoma: exploring immunotherapeutic avenues for overcoming immune suppression

P Jain, S Vashist, BK Panjiyar - Cureus, 2023 - ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM) is a primary brain tumor known for its short survival time,
typically 14-18 months from diagnosis to fatality. Managing GBM poses significant …

Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

N Nelson, A Relógio - NPJ Precision Oncology, 2024 - nature.com
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major
successes. This underlines the necessity to understand glioblastoma biology on other levels …

Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma

A Repici, A Ardizzone, F De Luca, L Colarossi… - Cells, 2024 - mdpi.com
Brain tumors are a diverse collection of neoplasms affecting the brain with a high prevalence
rate in people of all ages around the globe. In this pathological context, glioblastoma, a form …