Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …

Hypertrophic scarring, an abnormal fibroproliferative wound‐healing disease, has brought
tremendous burden for global healthcare systems. To date, no satisfactory treatment of …

Tissue-resident fibroblasts are mesenchymal cells which possess an impressive plasticity in
their ability to modify their properties according to the requirements of the microenvironment …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix
proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified …

It is a challenging clinical task to determine how to repair large-area skin defects better.
Traditional wound dressings (eg, cotton and gauze) can only be used as a dressing; …

Fibro-adipogenic progenitors (FAPs) are key regulators of skeletal muscle regeneration and
homeostasis. However, dysregulation of these cells leads to fibro-fatty infiltration across …

The fibrous network of an extracellular matrix (ECM) possesses mechanical properties that
convey critical biological functions in cell mechanotransduction. Engineered fibrous …