OBJECTIVE: Ecallantide is a recombinant peptide in the same class as aprotinin that inhibits
plasma kallikrein, a major component of the contact coagulation and inflammatory cascades …

Perioperative bleeding is a cause of major blood loss and is associated with increased rates
of postoperative morbidity and mortality. To combat this, antifibrinolytic inhibitors of the …

A comment on this article appears in" Aprotinin and lysine analogues in high-risk cardiac
surgery." N Engl J Med. 2008 Sep 11; 359 (11): 1181; author reply 1181-2. A comment on …

OBJECTIVE: Factors contributing to postoperative complications include blood loss and a
heightened inflammatory response. The objective of this study was to test the hypothesis that …

A new family of antifibrinolytic drugs has been recently discovered, combining a triazole
moiety, an oxadiazolone, and a terminal amine. Two of the molecules of this family have …

Survival of tissue engineered constructs after implantation depends heavily on induction of a
vascular response in host tissue, promoting a quick anastomosis of the cellular graft …

The serine protease plasmin is ubiquitously expressed throughout the human body in the
form of the zymogen plasminogen. Conversion to active plasmin occurs through enzymatic …

Background: Significant blood loss is still one of the most frequent issues in spinal surgery.
There were different hemostatic methods to prevent blood loss during spinal surgery …

Background: Neonates undergoing open‐heart surgery are especially at risk for massive
bleeding and pronounced inflammation. The efficacy of aprotinin, a serine protease inhibitor …

Abstract Factor XIa (FXIa) inhibition by protease nexin-2 (PN2KPI) was compared with
trypsin inhibition by basic pancreatic trypsin inhibitor (BPTI). PN2KPI was a potent inhibitor …