The birth of “Dolly,” the first mammal cloned from an adult mammary epithelial cell,
abolished the decades-old scientific dogma implying that a terminally differentiated cell …

X chromosome inactivation represents one of the most dramatic examples of mono-allelic
gene expression and long-term gene-silencing in mammals. The key regulatory molecule …

Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning
efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in …

How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is
poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes …

Epigenetic reprogramming is thought to play an important role in the development of cloned
embryos reconstructed by somatic cell nuclear transfer (SCNT). In the present study …

Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits
transformation of a somatic cell into an undifferentiated zygote with the potential to develop …

Epigenetic aberrancies likely preclude correct and complete nuclear reprogramming
following somatic cell nuclear transfer (SCNT), and may underlie the observed reduced …

Fertile offspring from somatic cell nuclear transfer (SCNT) is the goal of most cloning
laboratories. For this process to be successful, a number of events must occur correctly. First …

Somatic cell nuclear transfer (SCNT) has a broad spectrum of potential applications,
including rescue of endangered species, production of transgenic animals, drug production …

Epigenetics is a mechanism that regulates gene expression independently of the underlying
DNA sequence, relying instead on the chemical modification of DNA and histone proteins …