Hepatic insulin clearance: mechanism and physiology
SM Najjar, G Perdomo - Physiology, 2019 - journals.physiology.org
Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …
CEACAM1 as a multi-purpose target for cancer immunotherapy
ABSTRACT CEACAM1 is an extensively studied cell surface molecule with established
functions in multiple cancer types, as well as in various compartments of the immune system …
functions in multiple cancer types, as well as in various compartments of the immune system …
CEACAM1 in liver injury, metabolic and immune regulation
AK Horst, SM Najjar, C Wagener, G Tiegs - International journal of …, 2018 - mdpi.com
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …
The vascular adventitia: an endogenous, omnipresent source of stem cells in the body
P Wörsdörfer, SR Mekala, J Bauer, F Edenhofer… - Pharmacology & …, 2017 - Elsevier
Until a decade ago it was believed that the wall of adult blood vessels exclusively contains
terminally differentiated cell types. A paradigm shift was unavoidable since studies from …
terminally differentiated cell types. A paradigm shift was unavoidable since studies from …
Active RhoA exerts an inhibitory effect on the homeostasis and angiogenic capacity of human endothelial cells
M Hauke, R Eckenstaler, A Ripperger… - Journal of the …, 2022 - Am Heart Assoc
Background The small GTPase RhoA (Ras homolog gene family, member A) regulates a
variety of cellular processes, including cell motility, proliferation, survival, and permeability …
variety of cellular processes, including cell motility, proliferation, survival, and permeability …
Inhibitory innate receptors and their potential role in transplantation
The regulatory arm of the immune system plays a crucial role in maintaining immune
tolerance and preventing excessive immune responses. Immune regulation comprises …
tolerance and preventing excessive immune responses. Immune regulation comprises …
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis
HE Ghadieh, L Russo, HT Muturi, SS Ghanem… - Metabolism, 2019 - Elsevier
Background CEACAM1 regulates insulin sensitivity by promoting insulin clearance.
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
L Russo, HT Muturi, HE Ghadieh, SS Ghanem… - Diabetologia, 2017 - Springer
Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)
Mounting epidemiological evidence points to an association between metabolic syndrome
and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH …
and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH …
The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis
Carcinoembryonic antigen (CEA)-related cell adhesion molecules belong to the
immunoglobulin superfamily, are expressed in a broad spectrum of tissues and cell types …
immunoglobulin superfamily, are expressed in a broad spectrum of tissues and cell types …