Arterial hypertension represents a major global health concern; more than one fourth of the
population is affected by high blood pressure. Albeit the underlying cause of the disease …

Thyroid hormones have long been known to have a range of effects on the cardiovascular
system. However, significant knowledge gaps exist concerning the precise molecular and …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Importance In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as
causal and treatable factors for cognitive decline. However, the scientific literature on these …

Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Background: Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis that causes
systemic inflammation in the body, leading to hypothyroidism and an enlargement of the …

Subclinical thyroid dysfunction (STD), presenting as subclinical hypothyroidism (SHypo) or
subclinical hyperthyroidism (SHyper), defined as abnormal serum thyrotropin (TSH) and …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Toxicological studies show that exposure to disinfection byproducts, including
trihalomethanes (THMs), negatively affects thyroid function; however, few epidemiological …

Background: Observational studies have demonstrated that variation in normal range thyroid
function is associated with major cardiovascular risk factors, including dyslipidemia …