Nearly half of the human genome consists of endogenous retroelements (EREs) and their
genetic remnants, a small fraction of which carry the potential to propagate in the host …

In mammalian DNA, cytosine occurs in several chemical forms, including unmodified
cytosine (C), 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine …

Background KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-
binding proteins in vertebrate genomes and appear to have evolved to silence transposable …

Transcription factor Krüppel-like factor 4 (Klf4), one of the factors directing cellular
reprogramming, recognizes the CpG dinucleotide (whether methylated or unmodified) within …

DNA methylation is an essential epigenetic modification involved in the maintenance of
genomic stability, preservation of cellular identity, and regulation of the transcriptional …

Abstract Forkhead box H1 (FoxH1) is an essential maternal pioneer factor during embryonic
development that binds to specific GG/GT-containing DNA target sequences. Here we have …

ZFP57 is a master regulator of genomic imprinting. It has both maternal and zygotic functions
that are partially redundant in maintaining DNA methylation at some imprinting control …

Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine
(mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-binding proteins …

C CAAT/e nhancer b inding p roteins (C/EBPs) regulate gene expression in a variety of
cells/tissues/organs, during a range of developmental stages, under both physiological and …

ZFP57 and ZFP445 maintain genomic imprinting in mouse embryos. We found DNA
methylation was lost at most examined imprinting control regions (ICRs) in mouse Zfp57 …