The crosstalk between the heart and kidney is carried out through various bidirectional
pathways. Cardiorenal syndrome (CRS) is a pathological condition in which acute or chronic …

The management of patients with complex comorbidity involving several organ systems can
use an approach focused on each organ system independently or can use an approach …

Objectives Cardiorenal syndrome type-3 (CRS-3) is an abrupt worsening of cardiac function
secondary to acute kidney injury. Mitochondrial dysfunction is a key pathological mechanism …

Dapagliflozin (DAPA) confers significant protection against heart and kidney diseases.
However, whether DAPA can alleviate type 4 cardiorenal syndrome (CRS-4)-related …

Chronic kidney disease (CKD) results in reduced kidney function, uremia, and accumulation
of uremic metabolites. Mitochondrial alterations have been suggested to play a role in the …

It has been suggested that mitochondrial dysfunction underlies the myocardial injury seen
following cardiorenal syndrome type 3 (CRS-3). Both mitophagy and the mitochondrial …

Mortality in acute kidney injury (AKI) remains very high, yet the cause of death is often failure
of extrarenal organs. We and others have demonstrated remote organ dysfunction after …

Damage to peritubular capillaries is a key process that contributes to acute kidney injury
(AKI) progression. Vascular endothelial growth factor A (VEGFA) plays a critical role in …

Hypertension is a pervasive and widespread health condition that poses a significant risk
factor for cardiovascular disease, which includes conditions such as heart attack, stroke, and …

Mortality in acute kidney injury (AKI) patients remains very high, although very important
advances in understanding the pathophysiology and in diagnosis and supportive care have …