The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle
control and mutation rates within the genes. Genomic instability is broadly classified into …

Hypermethylation of CpG islands is a phenomenon commonly observed during the
development and progression of human tumors. Detection of methylated-CpG islands in …

Background: Hypertension is a common disease of the cardiovascular system and one of
the main causes of mortality in the world. Its etiopathogenesis and molecular mechanisms …

Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …

The cytochromes P450 (CYPs) are very efficient catalysts of foreign compound metabolism
and are responsible for the major part of metabolism of clinically important drugs. The …

Bisulfite genomic sequencing is a widely used technique for analyzing cytosine-methylation
of DNA. By treating DNA with bisulfite, cytosine residues are deaminated to uracil, while …

Promoter hypermethylation is one of the putative mechanisms underlying the inactivation of
negative cell-cycle regulators. We examined whether the methylation status of p16INK4a …

Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of
normal and tumour vessels. In this report, we characterized the transcriptional activity of the …

Methylation at position 5 of cytosine in DNA is an important event in epigenetic changes of
cells, the methylation being linked to the control of gene functions. The DNA methylation can …