Since as early as 1867, molecular sensors have been recognized as being intelligent
“devices” capable of addressing a variety of issues related to our environment and health …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Kidney disease affects almost 15% of the US population, and prevalence is anticipated to
grow as the population ages and the obesity epidemic continues due to Western dietary …

Retrospective analyses and single-center prospective studies identify chronic metabolic
acidosis as an independent and modifiable risk factor for progression of CKD. In patients …

Electrolytes are essential for basic life functioning, such as maintaining electrical neutrality in
cells, generating and conducting action potentials in the nerves and muscles. Sodium …

Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex
vasculature of the kidney remains a daunting task. The molecular pathways that specify and …

Renal tubular acidosis (RTA) occurs when the kidneys are unable to maintain normal acid−
base homeostasis because of tubular defects in acid excretion or bicarbonate ion …

Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …

Successful organ transplantation between species is now possible, using genetic
modifications. This article aims to provide a comprehensive overview of the differences and …

Acid‐base homeostasis is crucial for normal physiology, metabolism, and functions of living
organisms. Thus, the development of effective techniques to monitor it either in vitro or in …