Vascular mechanotransduction

MJ Davis, S Earley, YS Li, S Chien - Physiological reviews, 2023 - journals.physiology.org
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Dietary capsaicin: a spicy way to improve cardio-metabolic health?

A Szallasi - Biomolecules, 2022 - mdpi.com
Today's sedentary lifestyle with too much food and too little exercise has made metabolic
syndrome a pandemic. Metabolic syndrome is a major risk factor for type-2 diabetes and …

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

WWS Yue, L Yuan, JM Braz, AI Basbaum, D Julius - Elife, 2022 - elifesciences.org
TRPV1, a capsaicin-and heat-activated ion channel, is expressed by peripheral nociceptors
and has been implicated in various inflammatory and neuropathic pain conditions. Although …

TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain

TKE Maximiano, JA Carneiro, V Fattori, WA Verri Jr - Cell Calcium, 2024 - Elsevier
In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …

Role of TRPV1 in electroacupuncture‐mediated signal to the primary sensory cortex during regulation of the swallowing function

S Yuan, B Qiu, Y Liang, B Deng, J Xu… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Electroacupuncture (EA) at the Lianquan (CV23) could alleviate swallowing
dysfunction. However, current knowledge of its neural modulation focused on the brain, with …

Role of transient receptor potential channels in the regulation of vascular tone

XQ Hu, L Zhang - Drug Discovery Today, 2024 - Elsevier
Vascular tone is a major element in the control of hemodynamics. Transient receptor
potential (TRP) channels conducting monovalent and/or divalent cations (eg Na+ and Ca …

The vanilloid (capsaicin) receptor TRPV1 in blood pressure regulation: a novel therapeutic target in hypertension?

A Szallasi - International journal of molecular sciences, 2023 - mdpi.com
Today's sedentary lifestyle with excess food and little exercise increases the number of
people with hypertension, a major risk factor for stroke. New knowledge of treatments in this …

Contribution of transient receptor potential vanilloid 1 (TRPV1) channel to cholinergic contraction of rat bladder smooth muscle

BR Sharopov, IB Philyppov, SI Yeliashov… - The Journal of …, 2024 - Wiley Online Library
Transient receptor potential vanilloid 1 (TRPV1) is a calcium‐permeable ion channel that is
gated by the pungent constituent of red chili pepper, capsaicin, and by related chemicals …

The effects of acute aerobic exercise on blood pressure, arterial function, and heart rate variability in men living with HIV

JP Barros, T de Paula, MFF Mediano… - Frontiers in …, 2021 - frontiersin.org
Purpose This study aims to investigate the effects of acute cycling on blood pressure (BP),
arterial function, and heart rate variability (HRV) in men living with HIV (MLHIV) using …

Cultured rat aortic vascular smooth muscle cells do not express a functional TRPV1

T Blažević, CI Ciotu, M Gold-Binder, EH Heiss… - Plos one, 2023 - journals.plos.org
We showed previously that capsaicin, an active compound of chili peppers, can inhibit
platelet-derived growth factor-induced proliferation in primary rat vascular smooth muscle …