Emerging evidence and treatment paradigm of non-small cell lung cancer

SYM Liu, MM Zheng, Y Pan, SY Liu, Y Li… - Journal of hematology & …, 2023 - Springer
Research on biomarker-driven therapy and immune check-point blockade in non-small cell
lung cancer (NSCLC) is rapidly evolving. The width and depth of clinical trials have also …

Emerging precision neoadjuvant systemic therapy for patients with resectable non-small cell lung cancer: current status and perspectives

LA Godoy, J Chen, W Ma, J Lally, KA Toomey… - Biomarker …, 2023 - Springer
Over the past decade, targeted therapy for oncogene-driven NSCLC and immune
checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved …

Tumor immune microenvironment predicts the pathologic response of neoadjuvant chemoimmunotherapy in non–small‐cell lung cancer

R Han, Y Zhang, T Wang, H Xiao, Z Luo… - Cancer …, 2023 - Wiley Online Library
The clinical outcome of resectable non–small‐cell lung cancer (NSCLC) patients receiving
neoadjuvant chemoimmunotherapy is good but varies greatly. In addition, the pathological …

Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma

J Feng, Y Lan, F Liu, Y Yuan, J Ge, S Wei… - NPJ Precision …, 2023 - nature.com
The genomic instability (GI)/homologous recombination deficiency (HRD) score, calculated
as the sum of the events of loss of heterozygosity (LOH), large-scale state transition (LST) …

Advances in efficacy prediction and monitoring of neoadjuvant immunotherapy for non-small cell lung cancer

Y Wang, S Huang, X Feng, W Xu, R Luo, Z Zhu… - Frontiers in …, 2023 - frontiersin.org
The use of immune checkpoint inhibitors (ICIs) has become mainstream in the treatment of
non-small cell lung cancer (NSCLC). The idea of harnessing the immune system to fight …

The role of molecular testing in pancreatic cancer

DB Zhen, RA Safyan, EQ Konick… - Therapeutic …, 2023 - journals.sagepub.com
Pancreatic ductal adenocarcinoma (PDA) is highly aggressive and has few treatment
options. To personalize therapy, it is critical to delineate molecular subtypes and understand …

Homologous recombination deficiency (HRD) in cutaneous oncology

FA Akinjiyan, R Morecroft, J Phillipps… - International journal of …, 2023 - mdpi.com
Skin cancers, including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma
(SCC), and melanoma, are the most common malignancies in the United States. Loss of …

Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC

Y Wang, X Zhang, G Chen, Q Xing, B Zhu, X Wang - Genes & Immunity, 2023 - nature.com
Abstract The ferredoxin 1 (FDX1) gene had been recently reported as a critical mediator of
cuproptosis, and without doubt, its roles in KIRC would be of importance. Hence, this paper …

PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer

N Ding, M Li, X Zhao - Scientific Reports, 2023 - nature.com
Studying the molecular mechanisms and regulatory functions of genes is crucial for
exploring new approaches and tactics in cancer therapy. Studies have shown that the …

Progress on neoadjuvant immunotherapy in resectable non-small cell lung cancer and potential biomarkers

X Wu, YF Chau, H Bai, X Zhuang, J Wang… - Frontiers in …, 2023 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are highly concerned in the treatment of non-small cell
lung cancer (NSCLC), represented by inhibitors of programmed death protein 1 (PD-1) and …