Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

Experimental work of the last two decades has revealed the general steps of the wound
healing process. This complex network has been organized in three sequential and …

The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Renal cell carcinoma (RCC) is one of the most common tumours of the urinary system, and
is insidious and not susceptible to chemoradiotherapy. As the most common subtype of RCC …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …

Background. This study is aimed at investigating the changes in relevant pathways and the
differential expression of related gene expression after ischemic stroke (IS) at the single‐cell …

Astrocytes have emerged for playing important roles in brain tissue repair; however, the
underlying mechanisms remain poorly understood. We show that acute injury and blood …

Increasing evidence shows that endothelial cells play critical roles in maintaining vascular
homeostasis, regulating vascular tone, inhibiting inflammatory response, suppressing lipid …