Acute spinal cord injury (SCI) is a serious traumatic event to the spinal cord with
considerable morbidity and mortality. This injury leads to short-and long-term variations in …

Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Traumatic brain injury (TBI), which leads to high mortality and morbidity, is a prominent
public health problem worldwide. Neuroinflammation involving microglia and astrocyte …

In response to NIH initiatives to investigate sex as a biological variable in preclinical animal
studies, researchers have increased their focus on male and female differences in …

Sensory perception and emotional disorders are disproportionally represented in men and
women and are thus thought to be modulated by different sex hormones in various …

Objective: Long non-coding RNAs (lncRNAs) exert a critical function in mediating
neuropathic pain (NP). MEG3, a novel lncRNA, contributes to astrocyte activation and …

Low back pain (LBP) seriously affects human quality of life. Intervertebral disc degeneration
(IVDD) is the main pathological factor that leads to LBP, but the pathological mechanism …

Background Central post-stroke pain (CPSP) is a chronic and intolerable neuropathic pain
syndrome following a cerebral vascular insult, which negatively impacts the quality of life of …

Abstract Gypenoside XVII (GP‑17), one of the dominant active components of Gynostemma
pentaphyllum, has been studied extensively and found to have a variety of pharmacological …

Spinal cord injury (SCI) causes secondary injury, accompanied by pathological changes
such as oxidative stress, inflammation and neuronal apoptosis. This leads to permanent …