Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …

Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

Although there have been major advances in the treatment of rheumatoid arthritis with the
advent of biological agents, the mechanisms that drive cytokine production and sustain …

Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial
cells and other cells in the joint can express and respond to cytokines and chemokines, and …

Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune
diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune …

Neutrophils are the most abundant cell type involved in the innate immune response. They
are rapidly recruited to sites of injury or infection where they engulf and kill invading …

Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …

Cytokines play a pivotal role in the pathogenesis of autoimmune diseases. The precise
triggers for the breakdown of self-tolerance and the subsequent events leading to the …

Cancer and inflammation are intimately linked due to specific oxidative processes in the
tumor microenvironment. Lipoxygenases are a versatile class of oxidative enzymes involved …