Virus-like particle vaccinology, from bench to bedside
MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …
The RTS, S malaria vaccine: Current impact and foundation for the future
JG Beeson, L Kurtovic, C Valim, KP Asante… - Science Translational …, 2022 - science.org
The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …
Malaria in 2022: Increasing challenges, cautious optimism
P Jagannathan, A Kakuru - Nature communications, 2022 - nature.com
Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …
though recent developments inspire optimism. This includes the approval of the world's first …
Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …
the world's population at risk of Plasmodium infections. The development of an effective …
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria
DO Odera, J Tuju, K Mwai, IN Nkumama… - Science Translational …, 2023 - science.org
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …
Host-malaria parasite interactions and impacts on mutual evolution
X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …
worldwide. Malaria parasites have been associated with their hosts for millions of years …
Targets of complement-fixing antibodies in protective immunity against malaria in children
Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …
Trends of antimalarial marine natural products: Progresses, challenges and opportunities
Y Hai, ZM Cai, PJ Li, MY Wei, CY Wang, YC Gu… - Natural Product …, 2022 - pubs.rsc.org
Covering 1972 to 2021 Malaria remains a significant public health problem in some regions
of the world. The great efforts to control malaria have been severely compromised due to the …
of the world. The great efforts to control malaria have been severely compromised due to the …
Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens
Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …
them as vaccine candidates and identify the most common variants for inclusion in vaccine …
Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria
FK Musasia, IN Nkumama, R Frank… - Nature …, 2022 - nature.com
Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation
but are rarely investigated in the context of acquired immunity against Plasmodium …
but are rarely investigated in the context of acquired immunity against Plasmodium …