Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

The RTS, S malaria vaccine: Current impact and foundation for the future

JG Beeson, L Kurtovic, C Valim, KP Asante… - Science Translational …, 2022 - science.org
The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …

Malaria in 2022: Increasing challenges, cautious optimism

P Jagannathan, A Kakuru - Nature communications, 2022 - nature.com
Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …

Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria

DO Odera, J Tuju, K Mwai, IN Nkumama… - Science Translational …, 2023 - science.org
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …

Host-malaria parasite interactions and impacts on mutual evolution

X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Targets of complement-fixing antibodies in protective immunity against malaria in children

L Reiling, MJ Boyle, MT White, DW Wilson… - Nature …, 2019 - nature.com
Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …

Trends of antimalarial marine natural products: Progresses, challenges and opportunities

Y Hai, ZM Cai, PJ Li, MY Wei, CY Wang, YC Gu… - Natural Product …, 2022 - pubs.rsc.org
Covering 1972 to 2021 Malaria remains a significant public health problem in some regions
of the world. The great efforts to control malaria have been severely compromised due to the …

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

MT Naung, E Martin, J Munro, S Mehra… - PLoS Computational …, 2022 - journals.plos.org
Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …

Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria

FK Musasia, IN Nkumama, R Frank… - Nature …, 2022 - nature.com
Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation
but are rarely investigated in the context of acquired immunity against Plasmodium …