T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the
treatment of inflammation-based diseases. Several scientific advancements, by both …

Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

Recently, it has been described that innate immune cells such as monocytes, macrophages,
and natural killer cells can develop a non-specific immune response induced by different …

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …

There is increasing evidence suggesting that Epstein-Barr virus infection is a causative
factor of multiple sclerosis (MS). Epstein-Barr virus (EBV) is a human herpesvirus, Human …

Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …

Ferroptosis, a novel type of regulated cell death mediated by iron-dependent lipid oxidation,
was discovered a decade ago. Significant progress has been made in our knowledge of …

Multiple sclerosis (MS) is an immune-inflammatory disease that attacks and damages
myelinated axons in the central nervous system (CNS) and causes nontraumatic …