Potential of Nano-Engineered Stem Cells in the Treatment of Multiple Sclerosis: A Comprehensive Review

S Ghosh, GK Bhatti, PK Sharma, R Kandimalla… - Cellular and Molecular …, 2024 - Springer
Multiple sclerosis (MS) is a chronic and degrading autoimmune disorder mainly targeting the
central nervous system, leading to progressive neurodegeneration, demyelination, and …

Phenethyl ester of rosmarinic acid ameliorates experimental autoimmune encephalomyelitis

G Stegnjaić, M Lazarević, DA Diamantis, N Djedović… - Immunology …, 2022 - Elsevier
Rosmarinic acid is a polyphenolic compound, abundantly present in herbs of the Lamiaceae
family. The aim of the study was to evaluate the immunomodulatory properties of a recently …

Integrating genetic and proteomic data to elucidate the association between immune system and blood-brain barrier dysfunction with multiple sclerosis risk and …

D Sun, R Wang, Q Du, H Chen, Z Shi, Y Zhang… - Journal of Affective …, 2024 - Elsevier
Background Immune system dysfunction and blood-brain barrier (BBB) impairment are
implicated in multiple sclerosis (MS) risk and severity. However, the causal relationships and …

[HTML][HTML] 2-Bromo-1, 4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis

C Yang, Y Ma, Q Lu, Y Qu, Y Li… - Journal of …, 2024 - jneuroinflammation.biomedcentral …
Treating Multiple sclerosis (MS), a well-known immune-mediated disease characterized by
axonal demyelination, is challenging due to its complex causes. Naphthalenedione, present …

Dietary Inflammatory Potential in Pediatric Diseases: A Narrative Review

M Tosi, C Montanari, F Bona, C Tricella, M Agostinelli… - Nutrients, 2023 - mdpi.com
Inflammatory status is one of the main drivers in the development of non-communicable
diseases (NCDs). Specific unhealthy dietary patterns and the growing consumption of ultra …

[HTML][HTML] An Overview of Multiple Sclerosis In Vitro Models

J Czpakowska, M Kałuża, P Szpakowski… - International Journal of …, 2024 - mdpi.com
Multiple sclerosis (MS) still poses a challenge in terms of complex etiology, not fully effective
methods of treatment, and lack of healing agents. This neurodegenerative condition …

Decoding the role of the CCL2/CCR2 axis in Alzheimer's disease and innovating therapeutic approaches: Keeping All options open

R Arfaei, N Mikaeili, F Daj, A Boroumand… - International …, 2024 - Elsevier
Abstract Alzheimer's disease (AD), as a neurodegenerative disorder, distresses the elderly
in large numbers and is characterized by β-amyloid (Aβ) accumulation, elevated tau protein …

A Dual Therapy of Nanostructured Lipid Carrier Loaded with Teriflunomide—A Dihydro-Orotate Dehydrogenase Inhibitor and an miR-155-Antagomir in Cuprizone …

TS Koduru, VN Gupta, B Veeranna, S Seetharaman - Pharmaceutics, 2023 - mdpi.com
The effective treatment of central nervous system (CNS) disorders such as multiple sclerosis
(MS) has been challenging due to the limited ability of therapeutic agents to cross the blood …

Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE

P Bianchimano, K Iwanowski, EM Smith, A Cantor… - Iscience, 2023 - cell.com
Studies have reported increased intestinal permeability in multiple sclerosis (MS) patients
and its mouse model experimental autoimmune encephalomyelitis (EAE). However, the …

[HTML][HTML] Differential gene expression in B cells and T helper cells following high-dose glucocorticoid therapy for multiple sclerosis relapse

M Hecker, B Fitzner, D Koczan, J Klehmet… - Biomedicine & …, 2024 - Elsevier
Background Despite remarkable advances in the therapy of multiple sclerosis (MS), patients
with MS may still experience relapses. High-dose short-term methylprednisolone (MP) …