Therapeutics of Alzheimer's disease: Past, present and future
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
[HTML][HTML] Serotonin modulation of cortical neurons and networks
The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR,
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …
Therapeutics of neurotransmitters in Alzheimer's disease
R Kandimalla, PH Reddy - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by the
loss of memory, multiple cognitive impairments and changes in the personality and …
loss of memory, multiple cognitive impairments and changes in the personality and …
The serotonergic system and cognitive function
D Švob Štrac, N Pivac, D Mück-Šeler - Translational neuroscience, 2016 - degruyter.com
Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …
and executive functions are characteristic features of both schizophrenia and Alzheimer's …
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
KD Alex, EA Pehek - Pharmacology & therapeutics, 2007 - Elsevier
The neurotransmitter dopamine (DA) has a long association with normal functions such as
motor control, cognition, and reward, as well as a number of syndromes including drug …
motor control, cognition, and reward, as well as a number of syndromes including drug …
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications
P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …
and dopamine (DA) interactions play a key role in normal and abnormal behavior …
A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory
MV King, CA Marsden, KCF Fone - Trends in pharmacological sciences, 2008 - cell.com
The serotonergic system is implicated in the neurobiological control of learning and memory,
both in healthy individuals and pathological disorders, although the underlying mechanisms …
both in healthy individuals and pathological disorders, although the underlying mechanisms …
Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function
E Dale, AL Pehrson, T Jeyarajah, Y Li, SC Leiser… - CNS …, 2016 - cambridge.org
The hippocampus plays an important role in emotional and cognitive processing, and both
of these domains are affected in patients with major depressive disorder (MDD). Extensive …
of these domains are affected in patients with major depressive disorder (MDD). Extensive …
Reversal of hippocampal neuronal maturation by serotonergic antidepressants
K Kobayashi, Y Ikeda, A Sakai… - Proceedings of the …, 2010 - National Acad Sciences
Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety
disorders, and increasing evidence suggests potential use of these drugs beyond current …
disorders, and increasing evidence suggests potential use of these drugs beyond current …
How serotonin receptors regulate morphogenic signalling in neurons
A Wirth, K Holst, E Ponimaskin - Progress in neurobiology, 2017 - Elsevier
Abstract Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …