Signaling pathways and targeted therapy for myocardial infarction
Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
Cellular mechanotransduction: from tension to function
F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
Rho-associated coiled-coil containing kinases (ROCK) structure, regulation, and functions
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …
Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …
[HTML][HTML] Antioxidants: Friend or foe?
R Sarangarajan, S Meera, R Rukkumani… - Asian Pacific journal of …, 2017 - Elsevier
Reactive oxygen species are the intermediates that are formed during the normal metabolic
process which are effectively neutralized by the antioxidant system of the body. Any …
process which are effectively neutralized by the antioxidant system of the body. Any …
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment
This study, using mouse embryonic fibroblast (MEF) cells derived from ROCK1−/− and
ROCK2−/− mice, is designed to dissect roles for ROCK1 and ROCK2 in regulating actin …
ROCK2−/− mice, is designed to dissect roles for ROCK1 and ROCK2 in regulating actin …
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases
JM Arencibia, D Pastor-Flores, AF Bauer… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β–induced fibrogenesis in human colonic myofibroblasts
LA Johnson, ES Rodansky, AJ Haak… - Inflammatory bowel …, 2014 - academic.oup.com
Background Ras homolog gene family, member A (RhoA)/Rho-associated coiled-coil
forming protein kinase signaling is a key pathway in multiple types of solid organ fibrosis …
forming protein kinase signaling is a key pathway in multiple types of solid organ fibrosis …
Reactive oxygen species and the cardiovascular system
YJHJ Taverne, AJJC Bogers… - … medicine and cellular …, 2013 - Wiley Online Library
Ever since the discovery of free radicals, many hypotheses on the deleterious actions of
reactive oxygen species (ROS) have been proposed. However, increasing evidence …
reactive oxygen species (ROS) have been proposed. However, increasing evidence …
GPCR signaling and cardiac function
LA Capote, RM Perez, A Lymperopoulos - European journal of …, 2015 - Elsevier
G protein-coupled receptors (GPCRs), such as β-adrenergic and angiotensin II receptors,
located in the membranes of all three major cardiac cell types, ie myocytes, fibroblasts and …
located in the membranes of all three major cardiac cell types, ie myocytes, fibroblasts and …