Introduction: Rho kinase (ROCK) plays a critical role in actin cytoskeleton organization and
is involved in diverse fundamental cellular functions such as contraction and gene …

As a major ingredient of Radix ginseng, ginsenoside Rg1 (Rg1) has been increasingly
recognized to benefit the heart condition, however, the rationale behind the role is not fully …

ABSTRACT Introduction: The Rho-kinases (ROCK), ROCK1 and ROCK2, are potent,
widespread biochemical modulators which have been extensively studied. Due to the …

Polygonum multiflorum Thunb.(He-shou-wu in Chinese), a Chinese botanical drug with a
long history, is widely used to treat a variety of chronic diseases in clinic, and has been …

Rosuvastatin is a fully synthetic statin wich acts by interfering with the endogenous synthesis
of cholesterol through competitively inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A …

Cardiac dysfunction may complicate the course of severe sepsis and septic shock with
significant implications for patient's survival. The basic pathophysiologic mechanisms …

Rho kinase inhibitors (ROCKi) have attracted growing multidisciplinary interest, particularly
in Ophthalmology where the question as to how they promote corneal endothelial healing …

Cardiovascular disorders are the world's major cause of death nowadays. To treat
cardiovascular diseases especially coronary artery diseases and hypertension, researchers …

Abstract Aims: The RhoA/ROCK pathway controls crucial biological processes involved in
cardiovascular pathophysiology, such as cytoskeleton dynamics, vascular smooth muscle …

Fibrosis, a disease characterized by an excess accumulation of extracellular matrix
components, could lead to organ failure and death, and is to blame for up to 45% of all …