Obesity and associated complications increasingly jeopardize global health and contribute
to the rapidly rising prevalence of type 2 diabetes mellitus and obesity-related diseases …

A pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025, were used To study
the effects of Rho-associated coiled-coil containing protein kinase (ROCK) 1 and 2 on two …

Spinal muscular atrophy (SMA) is the most common genetic disease causing infant death,
due to an extended loss of motoneurons. This neuromuscular disorder results from deletions …

BACKGROUND The orphan receptor G protein–coupled receptor 35 (GPR35) has been
associated with a range of diseases, including cancer, inflammatory bowel disease …

Atherosclerosis is a chronic inflammatory disease of the arteries characterized by the
accumulation of inflammatory cells in the arterial wall. Hypertension, dyslipidemia, and …

Background: Protein kinases are the enzymes involved in phosphorylation of different
proteins which leads to functional changes in those proteins. They belong to serine …

Background Vascular endothelial cell (EC) alignment in the direction of flow is an adaptive
response that protects against aortic diseases, such as atherosclerosis. The Rho GTP ases …

Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima
formation in vein graft failure following coronary artery bypass. However, there are currently …

Effects of a pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025 on
dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells as a model of …

The prevalence of high blood pressure (also known as hypertension) has steadily increased
over the last few decades. Known as a silent killer, hypertension increases the risk for …