Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …

BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …

Oxidative stress is a disturbance in the equilibrium among free radicals, reactive oxygen
species, and endogenous antioxidant defense mechanisms. Oxidative stress is a result of …

Glutathione peroxidase 3 (GPx3), a major scavenger of reactive oxygen species (ROS) in
plasma, acts as a redox signal modulator. However, the mechanism underlying GPx3 …

Maintenance of cellular redox control is pivotal for normal cellular functions and cell fate
decisions including cell death. Among the key cellular redox systems in mammals, the …

Chemopreventive activity of selenium (Se) may influence epigenome. In this review, we
have discussed two aspects of Se and epigenetics in cancer, related to (1) the association …

The incidence of thyroid cancer has been increased in the past few decades. GPX3 gene is
located in 5q23, which is frequently deleted in prostate cancer. Methylation of GPX3 was …

The toxic mechanism of cadmium-quantum dots (Cd-QDs) to organisms is still debating. In
this paper, it was found that Cd-QDs could induce adverse effects to kidney by entering into …

Gastric cancer remains the second leading cause of cancer-related death in the world. H.
pylori infection, a major risk factor for gastric cancer, generates high levels of reactive …

Introduction Glutathione peroxidases (GPxs) constitutes an enzyme family which has the
ability to reduce free hydrogen peroxide to water and lipid hydroperoxides to their …