Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19)
pandemic and to help the return to pre-pandemic normalcy. A great many vaccine …

Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design
and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends …

Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but
eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here …

HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …

Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …

The development of stabilized recombinant HIV envelope trimers that mimic the virion
surface molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV …

The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally
dynamic,,,,,,–. Imaging by single-molecule fluorescence resonance energy transfer …

The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …

Structure determination of the HIV‐1 envelope glycoprotein (Env) presented a number of
challenges, but several high‐resolution structures have now become available. In 2013 …