Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers

RP Ringe, G Ozorowski, K Rantalainen… - Journal of …, 2017 - Am Soc Microbiol
Native-like trimers of the SOSIP design are being developed as immunogens in human
immunodeficiency virus type 1 (HIV-1) vaccine development programs. These trimers …

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

M Medina-Ramírez, RW Sanders… - Current Opinion in HIV …, 2017 - journals.lww.com
Stabilized HIV-1 envelope glycoprotein trimers for vaccine u... : Current Opinion in HIV and
AIDS Stabilized HIV-1 envelope glycoprotein trimers for vaccine use : Current Opinion in HIV …

mRNA-based vaccines and mode of action

J Gergen, B Petsch - mRNA Vaccines, 2021 - Springer
In the past 20 years, the mRNA vaccine technology has evolved from the first proof of
concept to the first licensed vaccine against emerging pandemics such as SARS-CoV-2 …

Conjugation of native-like hiv-1 envelope trimers onto liposomes using edc/sulfo-nhs chemistry: Requirements and limitations

E Suleiman, J Mayer, E Lehner, B Kohlhauser… - Pharmaceutics, 2020 - mdpi.com
The display of native-like human immunodeficiency virus type 1 envelope (HIV-1 Env)
trimers on liposomes has gained wide attention over the last few years. Currently, available …

Strategies for inducing effective neutralizing antibody responses against HIV-1

I del Moral-Sánchez, K Sliepen - Expert review of vaccines, 2019 - Taylor & Francis
Introduction: Despite intensive research efforts, there is still no effective prophylactic vaccine
available against HIV-1. Currently, substantial efforts are devoted to the development of …

Neutralizing antibody induction by HIV-1 envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin

RP Ringe, VM Cruz Portillo, P Dosenovic… - Journal of …, 2020 - Am Soc Microbiol
We covalently attached human immunodeficiency virus type 1 (HIV-1) Env SOSIP trimers to
iron oxide nanoparticles (IO-NPs) to create a particulate immunogen for neutralizing …

Production and immunogenicity of soluble plant-produced HIV-1 subtype C envelope gp140 immunogens

E Margolin, R Chapman, AE Meyers… - Frontiers in plant …, 2019 - frontiersin.org
The development of effective vaccines is urgently needed to curb the spread of human
immunodeficiency virus type 1 (HIV-1). A major focal point of current HIV vaccine research is …

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

CN Fries, JL Chen, ML Dennis, NL Votaw… - Scientific Reports, 2021 - nature.com
A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of
its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains …

Hiv/Aids vaccines: 2018

HL Robinson - Clinical Pharmacology & Therapeutics, 2018 - Wiley Online Library
Human immunodeficiency virus (HIV) has infected 76 million people and killed an estimated
35 million. During its 40‐year history, remarkable progress has been made on antiretroviral …

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro

G Ozorowski, A Cupo, M Golabek, M LoPiccolo… - Journal of …, 2018 - Am Soc Microbiol
Native-like, soluble, recombinant SOSIP trimers of various designs and based on several
env genes of human immunodeficiency virus type 1 (HIV-1) are being tested as …