Thymol (a phenol ring bearing active phytoconstituent) is a privileged scaffold, which is
diversified in natural sources. This scaffold acts as an obligatory template for scheming and …

Leishmaniasis is an emerging, uncontrolled, and neglected zoonotic disease. Climate
change is contributing to its ongoing global expansion. The dog is the main reservoir; hence …

Leishmania infantum, the etiological agent of canine leishmaniosis (CanL) in Europe, was
responsible of the largest outbreak of human leishmaniosis in Spain. The parasite infects …

Simple Summary Canine leishmaniosis is a complex infection that ranges from the apparent
absence of disease to a severe fatal clinical illness. Numerous epidemiological serosurveys …

Background Immunotherapeutic drugs, such as domperidone, have been shown to be
promising treatments against canine leishmaniosis (CanL), but limited data are available …

Abstract Background Domperidone (Leisguard®) is an immunomodulatory drug used as a
preventive measure in healthy dogs. However, no studies have been published in healthy …

There are several topical ectoparasiticides, drugs, supplements and vaccines that protect
dogs against sand fly bites and/or reduce the risk of Leishmania infantum infection. This …

Protozoan parasites represent a significant risk for public health worldwide, afflicting
particularly people in more vulnerable categories and cause large morbidity and heavy …

Background Chronic kidney disease (CKD) represents the main cause of mortality in dogs
with leishmaniosis. Domperidone has recently been reported to improve kidney function in …

Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public
health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs …