Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

The unique structural and functional features of CXCL12

R Janssens, S Struyf, P Proost - Cellular & molecular immunology, 2018 - nature.com
The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Antibody-induced procoagulant platelets in severe COVID-19 infection

K Althaus, I Marini, J Zlamal, L Pelzl… - Blood, The Journal …, 2021 - ashpublications.org
The pathophysiology of COVID-19–associated thrombosis seems to be multifactorial. We
hypothesized that COVID-19 is accompanied by procoagulant platelets with subsequent …

Platelet-derived HMGB1 is a critical mediator of thrombosis

S Vogel, R Bodenstein, Q Chen, S Feil… - The Journal of …, 2015 - Am Soc Clin Investig
Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …

Evolving complexity of MIF signaling

SS Jankauskas, DWL Wong, R Bucala, S Djudjaj… - Cellular signalling, 2019 - Elsevier
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

Current concepts and novel targets for antiplatelet therapy

M Gawaz, T Geisler, O Borst - Nature Reviews Cardiology, 2023 - nature.com
Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives

L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

The role of selected chemokines and their receptors in the development of gliomas

M Groblewska, A Litman-Zawadzka… - International journal of …, 2020 - mdpi.com
Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP‐70 signaling, and lymphocyte chemotaxis

S Alampour‐Rajabi, O El Bounkari, A Rot… - The FASEB …, 2015 - Wiley Online Library
Macrophage migration‐inhibitory factor (MIF) is a pleiotropic cytokine with chemokine‐like
functions and is a mediator in numerous inflammatory conditions. Depending on the context …

Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

S Song, Z Xiao, FJ Dekker, GJ Poelarends… - Cellular and Molecular …, 2022 - Springer
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …