Elevated neutrophil count is associated with higher risk of major adverse cardiac events
including myocardial infarction and early development of heart failure. Neutrophils …

Survival of burn patients is contingent on effective wound healing, a complex process that
requires coordinated responses of myeloid cells and inflammatory pathways. NLRP3, which …

Hyperosmotic stress occurs in several diseases, but its long-term effects are largely
unknown. We used sorbitol-treated human fibroblasts in 3D culture to study the …

Significance: An understanding of the physiology of wound healing and scarring is
necessary to minimize surgical scar formation. By reducing tension across the healing …

Damage to epidermis results in loss of barrier function and resultant pathological
inflammatory signaling, triggering further damage to the skin. Here we investigate …

Patients with cystic fibrosis (CF) experience severe lung disease, including persistent
infections, inflammation, and irreversible fibrotic remodeling of the airways. Although therapy …

The process of skin wound healing involves the following three steps: inflammation, tissue
formation and tissue remodelling. These optimal steps are required for the development of …

Atopic dermatitis (AD) is an inflammatory skin disorder caused by immunological
dysregulation and genetic factors. Whether the expression levels of cytokine and skin barrier …

Background Non-invasive biomarkers for the assessment of disease severity in idiopathic
pulmonary fibrosis (IPF) are urgently needed. Calprotectin belongs to the S-100 proteins …

Human skin wound repair may result in various outcomes with most of them leading to scar
formation. Commonly seen in many cutaneous wound healing cases, hypertrophic scars are …