Contribution of adipogenesis to healthy adipose tissue expansion in obesity

L Vishvanath, RK Gupta - The Journal of clinical …, 2019 - Am Soc Clin Investig
The manner in which white adipose tissue (WAT) expands and remodels directly impacts the
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …

Adipogenesis: a complex interplay of multiple molecular determinants and pathways

MA Ambele, P Dhanraj, R Giles, MS Pepper - International journal of …, 2020 - mdpi.com
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

[HTML][HTML] Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution

AK Sárvári, EL Van Hauwaert, LK Markussen… - Cell metabolism, 2021 - cell.com
Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

L Zhong, L Yao, RJ Tower, Y Wei, Z Miao, J Park… - elife, 2020 - elifesciences.org
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The importance of breast adipose tissue in breast cancer

C Kothari, C Diorio, F Durocher - International journal of molecular …, 2020 - mdpi.com
Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

[HTML][HTML] PARPs in lipid metabolism and related diseases

M Szántó, R Gupte, WL Kraus, P Pacher… - Progress in Lipid Research, 2021 - Elsevier
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

[HTML][HTML] Genome engineering via gene editing technologies in microalgae

B Jeong, J Jang, ES Jin - Bioresource Technology, 2023 - Elsevier
CRISPR-Cas has revolutionized genetic modification with its comparative simplicity and
accuracy, and it can be used even at the genomic level. Microalgae are excellent feedstocks …

PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …

Bioactive peptides from food proteins as potential anti-obesity agents: Mechanisms of action and future perspectives

IT Suryaningtyas, JY Je - Trends in Food Science & Technology, 2023 - Elsevier
Background Obesity is a global health concern with limited treatment options due to side
effects and limited efficacy. Bioactive peptides (BAPs) derived from food proteins have …