Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
Physiological roles of Rho and Rho effectors in mammals
D Thumkeo, S Watanabe, S Narumiya - European journal of cell biology, 2013 - Elsevier
Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell
migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best …
migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best …
The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis
RS Knipe, AM Tager, JK Liao - Pharmacological reviews, 2015 - ASPET
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung scarring, short
median survival, and limited therapeutic options, creating great need for new pharmacologic …
median survival, and limited therapeutic options, creating great need for new pharmacologic …
Rho kinases in health and disease: from basic science to translational research
G Loirand - Pharmacological reviews, 2015 - ASPET
Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …
dynamics downstream of Rho GTPases that participate in the control of important …
Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial …
Background—By inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, statins not
only reduce cholesterol biosynthesis but also decrease the formation of isoprenoids, which …
only reduce cholesterol biosynthesis but also decrease the formation of isoprenoids, which …
Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease
Q Zhou, C Gensch, JK Liao - Trends in pharmacological sciences, 2011 - cell.com
ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil
Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
Redox regulation of the actin cytoskeleton and its role in the vascular system
Q Xu, LP Huff, M Fujii, KK Griendling - Free Radical Biology and Medicine, 2017 - Elsevier
The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical,
organizational and signaling roles. Because many cytoskeletal proteins are sensitive to …
organizational and signaling roles. Because many cytoskeletal proteins are sensitive to …
Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases
The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …
Rho kinase as a therapeutic target in cardiovascular disease
Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …