Understanding of the gut microbiome's role in human physiology developed rapidly in recent
years. Moreover, any alteration of this microenvironment could lead to a pathophysiological …

The gut microbiome plays critical roles in human health and disease. Recent studies
suggest it may also be associated with chronic pain and postoperative pain outcomes. In …

Chronic pain remains one of the world's most persistent and unsolved clinical challenges
that severely affect patients' quality of life. Presently, considering that the mechanisms …

Pain perception involves current stimulation in peripheral nociceptive nerves and the
subsequent stimulation of postsynaptic excitatory neurons in the spinal cord. Importantly, in …

Abstract Purpose of Review To examine the effects and interactions between gut microbia
and chronic pain. Recent Findings The gut microbiome has been an area of interest in both …

Fabry disease (FD) is an X-linked metabolic disease caused by a deficiency in α-
galactosidase A (α-Gal A) activity. This causes accumulation of glycosphingolipids …

Traumatic brain injury (TBI) causes neuroinflammation and neurodegeneration, both of
which increase the risk and accelerate the progression of Alzheimer's disease (AD). The gut …

There has been a rapid increase in neonates born with a history of prenatal opioid
exposure. How prenatal opioid exposure affects pain sensitivity in offspring is of interest, as …

Visceral hypersensitivity, a fundamental mechanism of chronic visceral pain disorders, can
result from both central or peripheral factors, or their combination. As an important regulator …

Irritable bowel syndrome (IBS) is a chronic functional disorder which alters gastrointestinal
(GI) functions, thus leading to compromised health status. Pathophysiology of IBS is not fully …