Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …

Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …

Organoids are in vitro model systems that mimic the complexity of organs with multicellular
structures and functions, which provide great potential for biomedical and tissue …

In the last few decades, we have witnessed the great advances of molecular self-assembly
in biomedical applications. Among the building blocks for molecular self-assembly, peptide …

Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

Extracellular matrix regulates hallmark features of cancer through biochemical and
mechanical signals, although mechanistic understanding of these processes remains limited …

Organoids are biomimetic tissue analogs that are generated via the self‐organization of
stem cells or adult cells relying on developmental biology principles. They present tissue …

Human organotypic and organoid cultures provide increasingly life‐like models of
tissue/organ development and disease, enable more realistic drug screening, and may …

As life expectancy improves and the number of people suffering from various diseases
increases, the need for developing effective personalized disease models is rapidly rising …